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To reduce number of adverse events 2020 American College of Rheumatology Guideline for the Management of Gout to use colchicine in low dosages¹⁴.

Low dose regimen of colchicine leads considerably
improved safety profile

With the new low dose regimen side effects are dramatically
reduced and the treatment is much better tolerated!

Incidence of most frequent adverse events¹⁵

With low dose colchicine the incidence of severe diarrhea
is significantly reduced to level closed as placebo!

CI – Confidence interval

Comparative effectiveness of low dose vs high dose colchicine¹⁵

Improved pain patients with ≥ 50% reduction in pain after 24 hours

Low dose colchicine was as effective as high dose colchicine, but with a safety profile comparable to thatof a placebo.

Acute gout flare onset requires therapy initiation within 12 hours.

Advantages of low dose colchicine therapy:

Significantly less side effects than high dose
Same efficacy as high dose

GOUT treatment

Reduction of inflammation

The common symptoms of gout flares are inflammation and pain.

Pain management

There are several options given to provide gout pain relief. It is important to prescribe medicines which eliminate the inflammation as well.

Lowering uric acid levels

The treatment of gout aims to relieve pain and inflammation during attacks, and lower uric acid levels in the blood.

Treatment guidelines

Role of colchicine for acute gout flare & prevention gout treatment.

2020 American College of Rheumatology Guideline for the Management of Gout

Terkeltaub R.A., Furst D.E., Bennett K. et al. High versus low dosing of oral colchicine for early acute gout are: Twenty-four-hour outcome of the rst multicentre, rand omized, double-blind, placebo-controlled, parallel group, dose comparison colchicine study // Arthritis Rheum. – 2010. – №62. – Р. 1060-1068.

Optimal colchicine dosages

GOUT treatment

Reduction of inflammation

Pain management

Lowering uric acid levels

Treatment guidelines