Triggers & gout manifestation

Gout triggers can different from one person to another

  • Purine-rich foods

    Eating large amounts of foods high in purines including red meat, organ meat and shellfish can trigger flares

  • Excessive intake of alcohol

    Especially beer or grain liquors, or binge drinking

  • Crash diets

    This especially includes high-protein fad diets. Patient should consult a doctor before making any sudden dietary changes.

  • Starting uric-acid lowering medicines

    Although treating gout with uric acid-lowering medications is important for many gout sufferers and is often the best long-term solution for controlling gout starting, a new medication can trigger flares. If gout symptoms seem to be developing after starting medication, patient should call the medical professional who prescribed the medication before stopping treatment.

  • Radiation therapy – radiotherapy is associated with increased oxidative damage to DNA

    Radiation therapy – radiotherapy is associated with increased oxidative damage to DNA7.

DNA = Deoxyribonucleic Acid

Gout arthritis is extremely painful. Patients experiencing a gout flare regularly rate their level of pain as a 9 or 10 on a standard pain scale When gout is in its intermittent stage, most flares last for 5-7 days.

Common triggers for gout attacks

High intake of purine-rich foods

Stressful life
events

Illnes or injury

Medications

Excessive
alcohol intake

Rapid weight
changes

Overeating or
fasting

Dehydration

The signs and symptoms of gout almost always occur suddenly and often at night.

  • Sudden intense joint pain. Gout usually affects the big toe, but it can occur in any joint. Other commonly affected joints include the ankles, knees, elbows, wrists and fingers. The pain is likely to be most severe within the first four to 12 hours after it begins.
  • Lingering discomfort. After the most severe pain subsides, some joint discomfort may last from a few days to a few weeks. Later attacks are likely to last longer and affect more joints.
  • Inflammation and redness. The affected joint or joints become swollen, tender, warm and red.
  • Limited mobility. As gout progresses, patient may not be able to move your joints normally.
  • Tophi: In some cases, collections of uric acid crystals called tophi may develop under the skin around the affected joint. Tophi can be hard and lumpy and may cause the skin to become discolored or peel.
  • Fatigue and fever: During a gout attack, it is not uncommon to feel fatigued and feverish, as the body’s immune system responds to the inflammation in the joint

GOUT overview

Uric acid

Uric acid is a chemical created when the body breaks down substances called purines.

Inflammation and pain

Gout is now the most common cause of inflammatory arthritis.

Diagnosis

Gout diagnose is usually made based on patient symptoms and the appearance of the affected joint.

Stages

It is important to manage gout during all stages to prevent the progression of the disease and reduce the risk of future attacks.

Prevelance

The global population of individuals with gout increased in the past 30 years from 22 million to 53 million.

  1. Crohns M, Saarelainen S, Kankaanranta H, Moilanen E, Alho H, Kellokumpu-Lehtinen P. Local and systemic oxidant/antioxidant status before and during lung cancer radiotherapy.